Single-locus CRISPR/Cas9 based GD exhibit continuous super-Mendelian inheritance bias in small cage populations of Aedes aegypti.

A.) Schematic of the single-locus, CRISPR/Cas9 based GD transgenes, and the eye marker transgene (non-GD control) at the C109 locus [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011757#pgen.1011757.ref021" target="_blank&qu...

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Bibliographic Details
Main Author:	Zachary J. Speth (21609071) (author)
Other Authors:	David G. Rehard (5512646) (author), Patricia J. Norton (21609074) (author), Alexander W.E. Franz (21609077) (author)
Published:	2025
Subjects:	Microbiology Cell Biology Genetics Molecular Biology Biotechnology Evolutionary Biology Ecology Cancer Science Policy Computational Biology Biological Sciences not elsewhere classified yellow fever mosquito preexisting data sets potential fitness effects arboviruses including dengue antiviral effector construct cage trial observations engineered mosquitoes need maternal cas9 deposition specific homing rates mosquito population replacement small cage populations aedes aegypti </ low release threshold >- gd populations cas9 based gd population replacement cage populations aegypti </ >- gd susceptible mosquitoes zpg </ nanos </ cas9 expression populations harboring gd ). type males two low study demonstrates relative contributions predominant vector pooled samples mendelian inheritance gene drive discrete generation corresponding increases chikungunya viruses allele frequencies 16 generations
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Single-locus CRISPR/Cas9 based GD exhibit continuous super-Mendelian inheritance bias in small cage populations of <i>Aedes aegypti.</i>

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