Data Sheet 1_Off-target autophagy disruption associated with a novel liver toxicity in dogs for a highly basic heterobifunctional protein degrader.docx

Data Sheet 1_Off-target autophagy disruption associated with a novel liver toxicity in dogs for a highly basic heterobifunctional protein degrader.docx

Introduction<p>The observation of hepatobiliary toxicity in a repeat-dose Good Laboratory Practice-compliant dog toxicology study was a primary driver for the deprioritization of a preclinical heterobifunctional protein degrader candidate, Compound X. The pathology of large bile duct epithelia...

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Autor Principal: James E. Kath (9653107) (author)
Outros autores: Rebecca Kohnken (9559298) (author), Timothy Brayman (22817309) (author), Junhai Yang (1335093) (author), Katharina Haag (4871734) (author), Jingyi Gong (94287) (author), Christopher Untucht (128734) (author), Christiane Imhof (22591733) (author), Kenneth P. Robinson (1860313) (author), Ryan A. McClure (1378563) (author), James W. Sawicki (10686402) (author), Alexander Buzenski (22817312) (author), Rita Ciurlionis (13321) (author), Asra Habibullah (22817315) (author), Bo Liu (127343) (author), Christian Pohl (476404) (author), Zhaozhong Jia (22817318) (author), Spencer O. Scholz (22416711) (author), Lise I. Loberg (15071383) (author), Alexey Rivkin (1730611) (author)
Publicado: 2025
Subjects:
Pharmacology
degrader
bile duct
cholangiocyte
pKa
phospholipidosis
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