Faster force-effective migration despite reducing substrate stiffness and duration of collagen alignment.

Phase contrast images of cell monolayer migrating of softer (a) AF and (b) RF. (c, d) Maps of velocity component vx. (e, f<...

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Bibliographic Details
Main Author:	Amrit Bagchi (20536044) (author)
Other Authors:	Bapi Sarker (636603) (author), Jialiang Zhang (1574704) (author), Marcus Foston (2113672) (author), Amit Pathak (225960) (author)
Published:	2025
Subjects:	Biophysics Cell Biology Physiology Biotechnology Developmental Biology Plasma Physics Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified simultaneous compressive loading new paradigm wherein increasing ligand connectivity division based fluidization cause directed migration minimizing shear stresses aligned fibers serve aligned collagen fibers edge stabilization determines fast yet force cell clusters adhered normal stresses deeper increases migration efficiency div >< p also model ‘< normal stresses random fibers rapid stabilization capture ‘< ‘ force proportional force increased cell cell monolayer cell collectives use forces substrate deformation substrate connections speed relationship spatial propagation soft </ rf ). parallel fiber novel motor move forward motility waves motile entities migrating front migrate faster matrix exoskeleton haptotaxis </ findings reveal effective mode contractile forces clutch model cellular mechanotransduction active conduits
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