Delayed ISG induction in MARV infection and dysregulation of diarrhea-associated genes in EBOV- and MARV-infected human colonic organoids.

(A) Heatmap displaying the 250 most variable genes across all time points in EBOV- and MARV-infected HCOs. Differentially expressed genes (DEGs) with the most significant upregulation and downregulation at 1 and 3 dpi are highlighted in red. (B) Heatmap...

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1. Verfasser:	Elizabeth Y. Flores (22676699) (author)
Weitere Verfasser:	Adam J. Hume (6107039) (author), Judith Olejnik (367849) (author), Aditya Mithal (22676702) (author), Andrew D’Amico (2248762) (author), MengWei Yang (22676705) (author), Pushpinder Bawa (733756) (author), Feiya Wang (21075016) (author), Aoife K. O’Connell (15462382) (author), Anna Tseng (20843165) (author), Nicholas A. Crossland (5500244) (author), Gustavo Mostoslavsky (110612) (author), Elke Mühlberger (45516) (author)
Veröffentlicht:	2025
Schlagworte:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Biotechnology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified xlink "> gastrointestinal support viral replication providing mechanistic insight induced secretory diarrhea colonic epithelial responses model ebola virus mediated ion transport human gi pathology ion transport severe diarrhea human ipsc stimulated genes specific induction powerful system pathogen interactions marburg virus junctional disruption including apical filovirus disease filoviral disease dissect host delayed virus colonic organoids central contributor
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Zusammenfassung:	<p><b>(A)</b> Heatmap displaying the 250 most variable genes across all time points in EBOV- and MARV-infected HCOs. Differentially expressed genes (DEGs) with the most significant upregulation and downregulation at 1 and 3 dpi are highlighted in red. <b>(B)</b> Heatmap illustrating logFC expression values of interferon-stimulated genes (ISGs) in EBOV- and MARV-infected distal HIOs at 1 and 3 dpi. <b>(C)</b> Heatmap showing logFC expression values for a curated panel of genes implicated in diarrheal pathogenesis, measured in HCOs following EBOV and MARV infection at 1 and 3 dpi. <b>(D)</b> Heatmap representing logFC expression levels of genes involved in hypoxia responses in EBOV- and MARV-infected distal HIOs at 1 and 3 dpi. Key logFC changes in gene expression are annotated on the right of each heatmap.</p>

Delayed ISG induction in MARV infection and dysregulation of diarrhea-associated genes in EBOV- and MARV-infected human colonic organoids.

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