Delayed ISG induction in MARV infection and dysregulation of diarrhea-associated genes in EBOV- and MARV-infected human colonic organoids.

Delayed ISG induction in MARV infection and dysregulation of diarrhea-associated genes in EBOV- and MARV-infected human colonic organoids.

<p><b>(A)</b> Heatmap displaying the 250 most variable genes across all time points in EBOV- and MARV-infected HCOs. Differentially expressed genes (DEGs) with the most significant upregulation and downregulation at 1 and 3 dpi are highlighted in red. <b>(B)</b> Heatmap...

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Bibliographic Details
Main Author: Elizabeth Y. Flores (22676699) (author)
Other Authors: Adam J. Hume (6107039) (author), Judith Olejnik (367849) (author), Aditya Mithal (22676702) (author), Andrew D’Amico (2248762) (author), MengWei Yang (22676705) (author), Pushpinder Bawa (733756) (author), Feiya Wang (21075016) (author), Aoife K. O’Connell (15462382) (author), Anna Tseng (20843165) (author), Nicholas A. Crossland (5500244) (author), Gustavo Mostoslavsky (110612) (author), Elke Mühlberger (45516) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Cell Biology
Genetics
Molecular Biology
Physiology
Biotechnology
Immunology
Cancer
Mental Health
Infectious Diseases
Plant Biology
Virology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
xlink "> gastrointestinal
support viral replication
providing mechanistic insight
induced secretory diarrhea
colonic epithelial responses
model ebola virus
mediated ion transport
human gi pathology
ion transport
severe diarrhea
human ipsc
stimulated genes
specific induction
powerful system
pathogen interactions
marburg virus
junctional disruption
including apical
filovirus disease
filoviral disease
dissect host
delayed virus
colonic organoids
central contributor
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Summary:<p><b>(A)</b> Heatmap displaying the 250 most variable genes across all time points in EBOV- and MARV-infected HCOs. Differentially expressed genes (DEGs) with the most significant upregulation and downregulation at 1 and 3 dpi are highlighted in red. <b>(B)</b> Heatmap illustrating logFC expression values of interferon-stimulated genes (ISGs) in EBOV- and MARV-infected distal HIOs at 1 and 3 dpi. <b>(C)</b> Heatmap showing logFC expression values for a curated panel of genes implicated in diarrheal pathogenesis, measured in HCOs following EBOV and MARV infection at 1 and 3 dpi. <b>(D)</b> Heatmap representing logFC expression levels of genes involved in hypoxia responses in EBOV- and MARV-infected distal HIOs at 1 and 3 dpi. Key logFC changes in gene expression are annotated on the right of each heatmap.</p>

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