Delayed ISG induction in MARV infection and dysregulation of diarrhea-associated genes in EBOV- and MARV-infected human colonic organoids.
<p><b>(A)</b> Heatmap displaying the 250 most variable genes across all time points in EBOV- and MARV-infected HCOs. Differentially expressed genes (DEGs) with the most significant upregulation and downregulation at 1 and 3 dpi are highlighted in red. <b>(B)</b> Heatmap...
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2025
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| 总结: | <p><b>(A)</b> Heatmap displaying the 250 most variable genes across all time points in EBOV- and MARV-infected HCOs. Differentially expressed genes (DEGs) with the most significant upregulation and downregulation at 1 and 3 dpi are highlighted in red. <b>(B)</b> Heatmap illustrating logFC expression values of interferon-stimulated genes (ISGs) in EBOV- and MARV-infected distal HIOs at 1 and 3 dpi. <b>(C)</b> Heatmap showing logFC expression values for a curated panel of genes implicated in diarrheal pathogenesis, measured in HCOs following EBOV and MARV infection at 1 and 3 dpi. <b>(D)</b> Heatmap representing logFC expression levels of genes involved in hypoxia responses in EBOV- and MARV-infected distal HIOs at 1 and 3 dpi. Key logFC changes in gene expression are annotated on the right of each heatmap.</p> |
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