Delayed ISG induction in MARV infection and dysregulation of diarrhea-associated genes in EBOV- and MARV-infected human colonic organoids.

(A) Heatmap displaying the 250 most variable genes across all time points in EBOV- and MARV-infected HCOs. Differentially expressed genes (DEGs) with the most significant upregulation and downregulation at 1 and 3 dpi are highlighted in red. (B) Heatmap...

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Autore principale:	Elizabeth Y. Flores (22676699) (author)
Altri autori:	Adam J. Hume (6107039) (author), Judith Olejnik (367849) (author), Aditya Mithal (22676702) (author), Andrew D’Amico (2248762) (author), MengWei Yang (22676705) (author), Pushpinder Bawa (733756) (author), Feiya Wang (21075016) (author), Aoife K. O’Connell (15462382) (author), Anna Tseng (20843165) (author), Nicholas A. Crossland (5500244) (author), Gustavo Mostoslavsky (110612) (author), Elke Mühlberger (45516) (author)
Pubblicazione:	2025
Soggetti:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Biotechnology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified xlink "> gastrointestinal support viral replication providing mechanistic insight induced secretory diarrhea colonic epithelial responses model ebola virus mediated ion transport human gi pathology ion transport severe diarrhea human ipsc stimulated genes specific induction powerful system pathogen interactions marburg virus junctional disruption including apical filovirus disease filoviral disease dissect host delayed virus colonic organoids central contributor
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Delayed ISG induction in MARV infection and dysregulation of diarrhea-associated genes in EBOV- and MARV-infected human colonic organoids.

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