Overcoming the Limitations of Transition-Metal Catalysis in the Chemoenzymatic Dynamic Kinetic Resolution (DKR) of Atropisomeric Bisnaphthols

Overcoming the Limitations of Transition-Metal Catalysis in the Chemoenzymatic Dynamic Kinetic Resolution (DKR) of Atropisomeric Bisnaphthols

Chemoenzymatic dynamic kinetic resolution (DKR), combining a metal racemization catalyst with an enzyme, has emerged as an elegant solution to transform racemic substrates into enantiopure products, while compatibility of dual catalysis is the key issue. Conventional solutions have utilized presynth...

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Bibliographic Details
Main Author: Kun Wang (134525) (author)
Other Authors: Wei Wang (17594) (author), Dingkai Lou (20113426) (author), Jie Zhang (64655) (author), Changli Chi (20113429) (author), Jan-E. Bäckvall (1354065) (author), Xiang Sheng (1778470) (author), Can Zhu (1312431) (author)
Published: 2024
Subjects:
Biophysics
Biochemistry
Molecular Biology
Biotechnology
Infectious Diseases
Astronomical and Space Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
bcp (< b
transform racemic substrates
copper catalyst via
efficient dkr method
dkr ), combining
allowing additional metal
access chiral binols
metal racemization catalyst
racemization mechanism
racemic derivatives
dual copper
metal catalysis
− π
successfully realized
situ </
rotation barrier
lipase lpl
key issue
high yields
good enantioselectivity
generally limited
firmly coordinates
enantiopure products
elegant solution
dual catalysis
dramatic decrease
conventional solutions
c </
axial rotation
anionic ligands
anion intermediate
>< sub
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