Overcoming the Limitations of Transition-Metal Catalysis in the Chemoenzymatic Dynamic Kinetic Resolution (DKR) of Atropisomeric Bisnaphthols

Chemoenzymatic dynamic kinetic resolution (DKR), combining a metal racemization catalyst with an enzyme, has emerged as an elegant solution to transform racemic substrates into enantiopure products, while compatibility of dual catalysis is the key issue. Conventional solutions have utilized presynth...

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المؤلف الرئيسي:	Kun Wang (134525) (author)
مؤلفون آخرون:	Wei Wang (17594) (author), Dingkai Lou (20113426) (author), Jie Zhang (64655) (author), Changli Chi (20113429) (author), Jan-E. Bäckvall (1354065) (author), Xiang Sheng (1778470) (author), Can Zhu (1312431) (author)
منشور في:	2024
الموضوعات:	Biophysics Biochemistry Molecular Biology Biotechnology Infectious Diseases Astronomical and Space Sciences not elsewhere classified Chemical Sciences not elsewhere classified bcp (< b transform racemic substrates copper catalyst via efficient dkr method dkr ), combining allowing additional metal access chiral binols metal racemization catalyst racemization mechanism racemic derivatives dual copper metal catalysis − π successfully realized situ </ rotation barrier lipase lpl key issue high yields good enantioselectivity generally limited firmly coordinates enantiopure products elegant solution dual catalysis dramatic decrease conventional solutions c </ axial rotation anionic ligands anion intermediate >< sub
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Overcoming the Limitations of Transition-Metal Catalysis in the Chemoenzymatic Dynamic Kinetic Resolution (DKR) of Atropisomeric Bisnaphthols

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