Expression of GRASP55 reduces SARS-CoV-2 assembly and secretion.

Expression of GRASP55 reduces SARS-CoV-2 assembly and secretion.

<p>(A) GRASP55 expression reduces SARS-CoV-2 infection. Huh7-ACE2 cells stably expressing GFP or GRASP55-GFP were infected with SARS-CoV-2 (MOI = 3) for 24 h and stained for nucleocapsid. Shown are representative fluorescence images from 15 random images of one representative replicate from th...

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Bibliographic Details
Main Author: Jianchao Zhang (7111139) (author)
Other Authors: Andrew Kennedy (3240165) (author), Daniel Macedo de Melo Jorge (18474747) (author), Lijuan Xing (578431) (author), Whitney Reid (21578711) (author), Sarah Bui (21578714) (author), Joseph Joppich (21578717) (author), Molly Rose (21578720) (author), Sevval Ercan (21578723) (author), Qiyi Tang (352533) (author), David Ginsburg (402494) (author), Andrew W. Tai (10149208) (author), Yanzhuang Wang (87532) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Cell Biology
Molecular Biology
Evolutionary Biology
Mental Health
Infectious Diseases
Virology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
potential therapeutic target
host endomembrane system
despite extensive investigation
grasp55 expression reduces
blocking endoplasmic reticulum
enveloped virus sars
modulate viral assembly
facilitate viral assembly
secretion </ p
viral secretion
regulates grasp55
blocking sars
2 assembly
xlink ">
tgn46 depletion
taken together
spike number
molecular mechanisms
19 pandemic
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