Toxicokinetic Modeling for Intermittent Dietary Uptake of Per- and Polyfluoroalkyl Substances by Zebrafish

Toxicokinetic Modeling for Intermittent Dietary Uptake of Per- and Polyfluoroalkyl Substances by Zebrafish

Dietary uptake plays an important role in fish bioaccumulation of per- and polyfluoroalkyl substances (PFAS). However, the existing toxicokinetic modeling for dietary uptake of PFAS is limited. In this study, adult zebrafish were exposed to diet-borne PFAS with diverse structures for 3 days, followe...

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Bibliographic Details
Main Author: Xiaohan Lin (8202087) (author)
Other Authors: Haotian Wang (1364100) (author), Jie Zhang (64655) (author), Guibin Jiang (343016) (author), Xinghui Xia (1549069) (author)
Published: 2025
Subjects:
Biochemistry
Physiology
Ecology
Inorganic Chemistry
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
elimination rate constant
12 day depuration
physiologically based toxicokinetic
internal body burden
dietary uptake kinetics
pfas level fluctuation
peak pfas level
toxicokinetic model framework
existing toxicokinetic modeling
intermittent dietary uptake
dietary uptake
toxicokinetic modeling
toxicokinetic models
whole body
model performance
intermittent feeding
pfas levels
pfas ).
borne pfas
tissue distribution
significant influence
robust estimation
polyfluoroalkyl substances
integration within
important role
feeding intervals
experimental measurements
diverse structures
assimilation efficiency
accurately describe
3 days
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