Toxicokinetic Modeling for Intermittent Dietary Uptake of Per- and Polyfluoroalkyl Substances by Zebrafish

Dietary uptake plays an important role in fish bioaccumulation of per- and polyfluoroalkyl substances (PFAS). However, the existing toxicokinetic modeling for dietary uptake of PFAS is limited. In this study, adult zebrafish were exposed to diet-borne PFAS with diverse structures for 3 days, followe...

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Bibliographic Details
Main Author:	Xiaohan Lin (8202087) (author)
Other Authors:	Haotian Wang (1364100) (author), Jie Zhang (64655) (author), Guibin Jiang (343016) (author), Xinghui Xia (1549069) (author)
Published:	2025
Subjects:	Biochemistry Physiology Ecology Inorganic Chemistry Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified elimination rate constant 12 day depuration physiologically based toxicokinetic internal body burden dietary uptake kinetics pfas level fluctuation peak pfas level toxicokinetic model framework existing toxicokinetic modeling intermittent dietary uptake dietary uptake toxicokinetic modeling toxicokinetic models whole body model performance intermittent feeding pfas levels pfas ). borne pfas tissue distribution significant influence robust estimation polyfluoroalkyl substances integration within important role feeding intervals experimental measurements diverse structures assimilation efficiency accurately describe 3 days
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Toxicokinetic Modeling for Intermittent Dietary Uptake of Per- and Polyfluoroalkyl Substances by Zebrafish

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