Human <i>YBX1</i> and <i>YBX3</i> functionally replace <i>cey-1</i> in memory <i>in vivo</i> and insertion of a rare SNV into <i>YBX3</i> disrupts ITM.

Human <i>YBX1</i> and <i>YBX3</i> functionally replace <i>cey-1</i> in memory <i>in vivo</i> and insertion of a rare SNV into <i>YBX3</i> disrupts ITM.

<p>(<b>A</b>) Diagram of workflow for humanizing <i>C</i>. <i>elegans</i> to express either human <i>YBX1</i> or human <i>YBX3</i>, then generating <i>YBX3</i> c.379A>T (p.Asn127Tyr). (<b>B</b>) Insertion of...

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Bibliographic Details
Main Author: Ashley N. Hayden (19871128) (author)
Other Authors: Katie L. Brandel (19871131) (author), Edward W. Pietryk (5777888) (author), Paul R. Merlau (19871134) (author), Priyadharshini Vijayakumar (19871137) (author), Emily J. Leptich (19871140) (author), Elizabeth S. Gaytan (19871143) (author), Meredith I. Williams (19871146) (author), Connie W. Ni (19871149) (author), Hsiao-Tuan Chao (4454008) (author), Jill A. Rosenfeld (9606199) (author), Rachel N. Arey (19871152) (author)
Published: 2024
Subjects:
Biochemistry
Neuroscience
Pharmacology
Evolutionary Biology
Immunology
Cancer
Mental Health
Infectious Diseases
Biological Sciences not elsewhere classified
test evolutionary conservation
single nucleotide variants
potential new source
behavioral screening reveals
potential functional significance
leveraging human datasets
></ u ><
reveal memory regulators
div >< p
x </ u
b </ u
identifies ybx dysfunction
binding protein required
20 conserved rbps
u ><
unknown significance
rbp dysfunction
human genome
conserved residue
binding proteins
ybxs </
ybx3 </
legans </
elegans </
e </
c </
3 </
study highlights
regulate translation
rbp family
promote memory
neurological symptoms
neurological phenotypes
neurological disorders
nervous system
memory ability
key symptom
functionally replace
cognitive impairments
closest ortholog
associative learning
000 rbps
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