Recording electrical activity from a human cortical organoid with 3D HD-MEA.

<p>A) Pictures of an organoid on chip are overlayed with the corresponding connectivity map (from left to right: baseline, + 1 mM, + 5 mM KCl). Connectivity maps are calculated using cross-correlation analysis (see Methods). Each link is color-coded based on its normalized correlation level. R...

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Κύριος συγγραφέας:	Lisa Mapelli (416979) (author)
Άλλοι συγγραφείς:	Danila Di Domenico (22184062) (author), Giacomo Sciacca (22184065) (author), Francesco Mainardi (16194623) (author), Alessandra Ottaviani (9928810) (author), Anita Monteverdi (13202808) (author), Mariateresa Tedesco (8065790) (author), Chiara Rosa Battaglia (22184068) (author), Simona Tritto (6427103) (author), Mauro Gandolfo (22184071) (author), Kilian Imfeld (22184074) (author), Stefanie Kiderlen (22184077) (author), Lukas Krainer (22184080) (author), Chiara Cervetto (309268) (author), Manuela Marcoli (309265) (author), Anson Sing (22184083) (author), Jimena Andersen (9435518) (author), Fikri Birey (22184086) (author), Steven A. Sloan (12490070) (author), Alessandro Maccione (172920) (author), Egidio D'Angelo (213390) (author)
Έκδοση:	2025
Θέματα:	Biochemistry Neuroscience Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified Information Systems not elsewhere classified sensor interface provided creating new opportunities complex spatiotemporal organization chemical compound diffusion high spatiotemporal resolution planar mea improving mea technology represents mea microneedles reached mea also resolved different brain regions biological brain models ex vivo </ enhanced electrophysiological recordings div >< p advanced 3d high acute brain slices obtaining high brain microcircuits vitro </ throughput recordings cerebellar slices acute cortico brain spheroids valuable tool spinal organoids specimen adhesion results show recent advances organoids obtained one side neural structure neural networks multiple sites microchannel network meas ), inner layers functional connectivity electrode arrays drug application 3d hd
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Recording electrical activity from a human cortical organoid with 3D HD-MEA.

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