Prediction of the time delay from a realistic distribution of AKAP/AC nanodomains but with FWHM (full width at half maximum) of 30 nm.

<p>(A) The dynamics of Ca<sup>2+</sup> and cAMP on the AKAP/AC nanodomain (i) and outside the AKAP/AC nanodomain (ii) when the initial distribution of AC is obtained in a similar way as <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012564#pcbi....

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Bibliographic Details
Main Author:	Lingxia Qiao (19996756) (author)
Other Authors:	Michael Getz (17692612) (author), Ben Gross (2993145) (author), Brian Tenner (138904) (author), Jin Zhang (53297) (author), Padmini Rangamani (4740435) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Microbiology Cell Biology Genetics Neuroscience Physiology Immunology Cancer Science Policy Biological Sciences not elsewhere classified previous experimental studies key circuit motif incoherent feedforward loop develop computational models adenylyl cyclase 8 two important predictions many cellular functions arbitrary phase difference div >< p camp peak simultaneously 2 +</ sup ac nanodomain formation phase oscillations associated enzymes associated two nanodomains ac nanodomains volume ratio turing pattern time delay spatiotemporal orchestration spatial compartmentation signaling molecules second messengers nanoscale organization low level governs camp give rise findings unveil ensuring compartmentation compartment size cellular surface camp oscillations
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Prediction of the time delay from a realistic distribution of AKAP/AC nanodomains but with FWHM (full width at half maximum) of 30 nm.

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