Atomistic Mechanism of Calcium-Mediated Inward Rectification of the MthK Potassium Channel by Solid-State NMR and MD Simulations

Inward rectification is a fundamental but poorly understood phenomenon in potassium channel physiology. Despite its physiological importance, the exact mechanism has remained elusive. In this work, we uncover a previously unrecognized calcium-mediated gating mechanism in the MthK potassium channel t...

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Bibliographic Details
Main Author:	Carl Öster (1345275) (author)
Other Authors:	Reinier de Vries (22750777) (author), Juan Li (146180) (author), Denis Qoraj (22750780) (author), Sascha Lange (1279854) (author), Chaowei Shi (7500977) (author), Wojciech Kopec (1708618) (author), Bert L de Groot (22750783) (author), Adam Lange (271750) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Inorganic Chemistry Hematology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified without water cotransport sheds new light potassium ions move potassium channel physiology poorly understood phenomenon mthk potassium channel mediated inward rectification mediated gating mechanism previously unrecognized calcium 2 +</ sup state nmr spectroscopy state nmr combining state ” mechanism exact mechanism atomistic mechanism site leads remained elusive physiological importance physically obstructing outward flow essential process art proton allows us
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Atomistic Mechanism of Calcium-Mediated Inward Rectification of the MthK Potassium Channel by Solid-State NMR and MD Simulations

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