S3 Fig -

S3 Fig -

<p><b>A,</b> Nasal lavage CFU from infant mice IN infected with either <i>Spn</i> T6A or <i>Spn</i> T4 at 3 dpi (n = 11–12). Data represent individual mice with mean ±SEM and are collected from 2 independent experiments. Statistical significance determined u...

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Main Author: Kristen L. Lokken-Toyli (9455263) (author)
Other Authors: Surya D. Aggarwal (5849162) (author), Gavyn Chern Wei Bee (16765028) (author), Wouter A. A. de Steenhuijsen Piters (18522849) (author), Cindy Wu (3238686) (author), Kenny Zhi Ming Chen (18522852) (author), Cynthia Loomis (10526353) (author), Debby Bogaert (23222) (author), Jeffrey N. Weiser (10526356) (author)
Published: 2024
Subjects:
Biochemistry
Medicine
Microbiology
Cell Biology
Genetics
Molecular Biology
Physiology
Immunology
Developmental Biology
Cancer
Infectious Diseases
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
using molecular barcoding
tight junction pathway
like receptor 2
forming toxin pneumolysin
first two weeks
delayed mucociliary clearance
streptococcus pneumoniae </
significantly decreased compared
drive bacterial spread
upregulate genes involved
postnatal development predisposes
div >< p
urt epithelium revealed
early life beyond
postnatal development
spn </
respiratory epithelium
early life
also decreased
bacterial clones
urt monocyte
urt barrier
transcriptional profiling
tighter attachment
survival rate
results demonstrate
pneumococcal bacteremia
newborn period
neutrophil infiltration
nasopharynx disseminated
invasive respiratory
inflammation mediated
infant mice
increased rate
highly susceptible
gastrointestinal infections
derived ros
dependent mechanism
colonization levels
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