Regulating Biocondensates within Synthetic Cells via Segregative Phase Separation

Living cells orchestrate a myriad of biological reactions within a highly complex and crowded environment. A major factor responsible for such seamless assembly is the preferential interactions between the constituent macromolecules, that can drive demixing to produce coexisting phases and thus prov...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Chang Chen (30907) (author)
مؤلفون آخرون:	Caroline M. Love (21191790) (author), Christopher F. Carnahan (21191793) (author), Ketan A. Ganar (16984745) (author), Atul N. Parikh (169046) (author), Siddharth Deshpande (705014) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Cell Biology Genetics Immunology Biological Sciences not elsewhere classified still largely unknown phase separation phenomena occurring simultaneously within major factor responsible global shape transformation distinct design principle chip microfluidic systems biological reactions within produce coexisting phases including membrane interaction multiple phases way multiple targeting agents spatial localization sized vesicles seamless assembly rich dynamics process initiation preferential interactions molecular recruiters molecular distribution molecular communication mimicking confinements lipid membrane lipid boundary isolated microenvironment highly complex hierarchical domains externally trigger drive demixing diffusive motion cytoplasmic space crowded environment constituent macromolecules
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Regulating Biocondensates within Synthetic Cells via Segregative Phase Separation

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