Activation of vMC-dDG pathway decreases the competitive advantage of fear engram cells in the dDG neuronal network and attenuates fear generalization.

<p>(A) Experimental design. Left: The vDG of Calb2-Cre mice were injected with AAV-hSyn-DIO-hM3D(Gq)-EGFP virus. Right: After virus expression, mice were subjected to CFC training under SS in context A. After 3 days, mice were intraperitoneally injected with saline (Saline group) or CNO (CNO g...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Kun Cui (2070772) (author)
مؤلفون آخرون:	Xuetao Qi (18243525) (author), Zilong Liu (548959) (author), Weiqi Sun (18787948) (author), Peijie Jiao (11647866) (author), Chang Liu (35901) (author), Jifu Tong (19118428) (author), Xiaoyan Sun (28501) (author), Haojie Sun (4516129) (author), Su Fu (4990886) (author), Jiaxin Wang (483624) (author), Yawen Zheng (6901787) (author), Tianyu Liu (529994) (author), Shuang Cui (2428774) (author), Fengyu Liu (250091) (author), Jian Mao (1424950) (author), Jie Zheng (31208) (author), You Wan (250092) (author), Ming Yi (15051) (author)
منشور في:	2024
الموضوعات:	Genetics Molecular Biology Neuroscience Cancer Mental Health Biological Sciences not elsewhere classified ventral dentate gyrus provide novel insights posttraumatic stress disorder photon calcium imaging dorsal dentate gyrus accurate memory retrieval contains engram cells significantly higher proportion safety &# 8221 neuronal subpopulations within fear engram cells mice </ p ddg neurons activated inducing fear generalization conditioned context constitutes fear generalization conditioned fear conditioned context mossy cells significantly suppressed neuronal basis &# 8220 generalized fear similar context xlink "> well understood system combined situations characteristic maladaptive response harmless stimuli findings reveal ddg pathway ddg network crucial role coordination mechanism competitive advantage anxiety disorders
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Activation of vMC-dDG pathway decreases the competitive advantage of fear engram cells in the dDG neuronal network and attenuates fear generalization.

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