Pan-Cancer Analysis of G Protein-Coupled Receptors as Cancer Driver Genes and Drug Repurposing Targets

Pan-Cancer Analysis of G Protein-Coupled Receptors as Cancer Driver Genes and Drug Repurposing Targets

G protein-coupled receptors (GPCRs), the largest family of currently approved drug targets, are rarely targeted for cancer therapy. There is limited research on the role of GPCRs in pan-cancer, particularly regarding the underlying causes of their abnormal expression. The abnormal expression of GPCR...

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Bibliographic Details
Main Author: Yue Hou (2562085) (author)
Other Authors: Yunqing Liu (553987) (author), Chongwen Pang (17822651) (author), Nianfeng Shi (17054492) (author), Xuan Huang (191597) (author), Changchang Cao (3478028) (author), Chuanjun Shu (6429623) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Genetics
Molecular Biology
Pharmacology
Mental Health
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
remain poorly understood
http :// gpcrpca
e ., theophyline
151 significant hr
11 signaling pathways
paad therapy patients
known drug targets
different expression analyses
customizable queries based
cancer driver genes
transcriptional regulatory elements
g4s ), superenhancers
related cancer analysis
mrna structure could
regulatory elements
mrna structure
cancer therapy
cancer analysis
drug repurposing
abnormal expression
cancer ),
based tool
related gpcrs
cancer prognosis
viennarna algorithms
utilizing precog
underlying causes
rarely targeted
provides fast
promoter methylation
particularly regarding
limited research
largest family
hazard ratios
four drugs
cox regression
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