Sequence comparison of var mapping reads in smart-seq data.

(A) Comparison of regions with sequencing coverage by smart-seq of an end-Dry season asymptomatic infection. Cells were clustered by var expression into 7 clusters indicated by color, and coverage of individual var domains in a refere...

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Main Author:	Sukai Ceesay (3472853) (author)
Other Authors:	Martin Kampmann (5688443) (author), Lasse Votborg-Novél (20138013) (author), Helle Smedegaard Hansson (21519864) (author), Rasmus Weisel Jensen (15216781) (author), Manuela Carrasquilla (2897933) (author), Hamidou Cisse (21519867) (author), Louise Turner (55117) (author), Usama Dabbas (21519870) (author), Christina Ntalla (20138016) (author), Silke Bandermann (3611189) (author), Safiatou Doumbo (248618) (author), Didier Doumtabe (248621) (author), Aissata Ongoiba (248615) (author), Kassoum Kayentao (248612) (author), Boubacar Traore (248609) (author), Peter D. Crompton (9462929) (author), Thomas Lavstsen (75520) (author), Silvia Portugal (3385946) (author)
Published:	2025
Subjects:	Microbiology Genetics Immunology Infectious Diseases Computational Biology Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified used bioinformatic tools upstream sequence type main determinant limiting achieved remains unknown severe malaria cases malaria cases compared term infections may seasonal transmission areas clinical malaria occurs clinical malaria cases div >< p plasmodium falciparum </ month dry season binding pfemp1 dominated asymptomatic carriers expressed malaria transmission clinical cases asymptomatic carriers falciparum </ subclinical infections clinical presentation wet season dry season binding phenotype binding pfemp1 vars </ var </ wet seasons transcripts attributed transcript variation transcript levels sustain long significant difference shows circulation sequenced expressed reduced cytoadhesion prolonged circulation parasite ’ malian children lower proportions lower levels larger proportion infected erythrocytes immune selection host ’ host immunity higher titers gene expression expresses fewer domain composition
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Sequence comparison of <i>var</i> mapping reads in smart-seq data.

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