Maximum sequence recovery of interface CDR3s amino acids in the presence or absence of pMHC structures.

<p><b>(A)</b> Bar plot displaying the maximum sequence recovery for each test case, with designs generated by ProteinMPNN shown on the top and those by ESM-IF1 on the bottom. Colored bars (purple or red) represent the CDR3 interface designs considering the corresponding pMHC comple...

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Bibliographic Details
Main Author:	Helder V. Ribeiro-Filho (15188347) (author)
Other Authors:	Gabriel E. Jara (19762506) (author), João V. S. Guerra (19762509) (author), Melyssa Cheung (17440005) (author), Nathaniel R. Felbinger (19762512) (author), José G. C. Pereira (19762515) (author), Brian G. Pierce (204648) (author), Paulo S. Lopes-de-Oliveira (15388693) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Biotechnology Immunology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified unique natural characteristics shown promising results mediating immune responses existing ones designed evaluate tcr designs different design scenarios infected target cells based design methods target protein based metrics based methods design field computational design treating diseases substantially impacted specific functions protein modeling particularly due novel proteins low affinity increasing set identifying deficiencies especially cancer designing fixed current physics crucial role comprehensive set classical physics cell receptors
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Maximum sequence recovery of interface CDR3s amino acids in the presence or absence of pMHC structures.

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