Filamin A phosphorylation is essential for ORF45-induced detachment and migration but not for virion production.

Filamin A phosphorylation is essential for ORF45-induced detachment and migration but not for virion production.

<p>A-D. HEK293 cells were transfected with Filamin A WT or S2152A mutated constructs and then infected with empty vector or ORF45-expressing lentiviruses at 8 h after transfection. Twenty-four hours later, the cell morphology was observed by inverted microscopy, and representative images are s...

पूर्ण विवरण

में बचाया:

ग्रंथसूची विवरण
मुख्य लेखक:	Xiaojuan Li (351842) (author)
अन्य लेखक:	Li Quan (177024) (author), Rihong Zhou (22676690) (author), Xiangpeng Liu (17898881) (author), Ronit Sarid (186795) (author), Ersheng Kuang (129028) (author)
प्रकाशित:	2025
विषय:	Microbiology Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology s2152a knockin abolish primary effusion lymphoma multicentric castleman disease kaposi &# 8217 mediated viral infection infected adherent cells differentiated b cells sequential cell detachment mediated kshv transmission kshv lytic replication adherent cells lytic replication viral transmission kshv transmission cell detachment b lymphocytes lytic cycle cell transmission taken together results demonstrated radically support natural donors key role key regulator etiological agent dependent manner cell contact cell adhesion associated herpesvirus
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समान संसाधन

Filamin A phosphorylation is induced by ORF45-mediated RSK activation.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

RSK inhibitors suppress ORF45-induced Filamin A phosphorylation.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

Filamin A KO and S2152A KI reduce KSHV de novo infection of cell-free virions.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

Filamin A KO and S2152A KI reduce cell migration under ORF45 overexpression or during KSHV de novo infection or lytic reactivation.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

The expression levels of Filamin A in KSHV-positive cells.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

Filamin A KO or S2152A KI does not affect KSHV lytic reactivation.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

Validation of Filamin A KO and S2152A KI stable HEK293-mcherry cells.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

Filamin A KO and S2152A KI in donor cells do not affect KSHV cell-to-cell viral transmission.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

Filamin A KO and S2152A KI reduce KSHV de novo infection and cell-contact mediated viral infection.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

ORF45 reduces cell adhesion through RSK activation.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

ORF45 promotes cell migration during early primary infection.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

The treatment of RSK inhibitors attenuates ORF45-increased ability of cell migration.
द्वारा: Xiaojuan Li (351842)
प्रकाशित: (2025)

Working model for the role of PPP2R1A in regulating the stability of RTA.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

RTA promotes PPP2R1A degradation through the ubiquitin-proteasome pathway during KSHV lytic replication.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

Phosphatase PP2A promotes RTA dephosphorylation at Thr42 and Thr678 to suppresses the transactivation activity of RTA.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

RTA dephosphorylation mediated by phosphatase PP2A impairs KSHV lytic replication.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

Phosphatase PP2A promotes RTA dephosphorylation.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

Ectopic expression of PPP2R1A impairs KSHV lytic replication.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

KSHV RTA interacts with the host protein PPP2R1A.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

Raw data.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

Primers used in this study.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

RTA dephosphorylation mediated by phosphatase PP2A is conserved among rhadinoviruses.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

PPP2R1A works as a major repressor of viral lytic genes during KSHV <i>de novo</i> infection.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

RTA promotes PPP2R1A degradation through the ubiquitin-proteasome pathway during KSHV lytic replication.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

Phosphatase PP2A promotes RTA dephosphorylation at Thr42 and Thr678 to suppresses the transactivation activity of RTA.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

RTA dephosphorylation mediated by phosphatase PP2A impairs KSHV lytic replication.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

Phosphatase PP2A promotes RTA dephosphorylation.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

Ectopic expression of PPP2R1A impairs KSHV lytic replication.
द्वारा: Lei Bai (631944)
प्रकाशित: (2025)

Spatial transcriptomics of Kaposi sarcoma lesions using 10X Genomics Visium platform with custom KSHV probes
द्वारा: Joseph Ziegelbauer (753193)
प्रकाशित: (2025)

Primer and synthesized DNA fragments used in this study.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

Schematic model of TR functions as an inducible enhancer for KSHV lytic gene transcription.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

BRD4 and LANA protein form LLPS.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

Experimental workflow of the isolation and the comparison of reactivated cBu-1 TR21- and TR6-KSHV infected iSLK cells.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

LANA NBs functions as transcription memory.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

Establishment of cBu-1 BAC16 for the isolation of reactivated cell population.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

BRD4 regulates KSHV inducible gene expression in the TR dependent manner.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

KSHV inducible gene expression is positively regulated in a TR-dependent manner.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

Generation of recombinant KSHV BAC with different numbers of TR copies.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

Raw data used to preapre presented figures are listed in the file.
द्वारा: Tomoki Inagaki (12903779)
प्रकाशित: (2025)

Key resources table.
द्वारा: Joyanta Biswas (18258322)
प्रकाशित: (2025)