Filamin A phosphorylation is essential for ORF45-induced detachment and migration but not for virion production.

<p>A-D. HEK293 cells were transfected with Filamin A WT or S2152A mutated constructs and then infected with empty vector or ORF45-expressing lentiviruses at 8 h after transfection. Twenty-four hours later, the cell morphology was observed by inverted microscopy, and representative images are s...

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Главный автор:	Xiaojuan Li (351842) (author)
Другие авторы:	Li Quan (177024) (author), Rihong Zhou (22676690) (author), Xiangpeng Liu (17898881) (author), Ronit Sarid (186795) (author), Ersheng Kuang (129028) (author)
Опубликовано:	2025
Предметы:	Microbiology Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology s2152a knockin abolish primary effusion lymphoma multicentric castleman disease kaposi &# 8217 mediated viral infection infected adherent cells differentiated b cells sequential cell detachment mediated kshv transmission kshv lytic replication adherent cells lytic replication viral transmission kshv transmission cell detachment b lymphocytes lytic cycle cell transmission taken together results demonstrated radically support natural donors key role key regulator etiological agent dependent manner cell contact cell adhesion associated herpesvirus
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Filamin A phosphorylation is essential for ORF45-induced detachment and migration but not for virion production.

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