Discovery of FLT3-ITD Inhibitor Clifutinib: A Novel Biphenylacetylene Urea Derivative in Clinical Trials for the Treatment of Relapsed/Refractory FLT3-ITD<sup>+</sup> Acute Myeloid Leukemia

Discovery of FLT3-ITD Inhibitor Clifutinib: A Novel Biphenylacetylene Urea Derivative in Clinical Trials for the Treatment of Relapsed/Refractory FLT3-ITD<sup>+</sup> Acute Myeloid Leukemia

Internal tandem duplication (ITD) mutations of FLT3 (FLT3-ITD) are a promising target for patients with acute myeloid leukemia (AML), given that they have been identified in the majority of AML patients and are associated with poor prognosis. Here, a series of biphenylacetylene derivatives was devel...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Bing Liu (70818) (author)
مؤلفون آخرون: Ning Kang (327210) (author), Fang Yang (123514) (author), WeiHong Zhang (21076156) (author), XingGuo Yan (21076159) (author), Heng Wang (76752) (author), Shun Bai (9365909) (author), Cliff C. Cheng (2115340) (author), Juan Xu (225010) (author), WenHao Hu (21076162) (author), YingJun Zhang (21076165) (author)
منشور في: 2025
الموضوعات:
Biochemistry
Medicine
Pharmacology
Biotechnology
Cancer
Hematology
Infectious Diseases
Chemical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
tumor growth inhibition
sup >+</ sup
exhibited excellent potency
displayed favorable drug
acute myeloid leukemia
aml ), given
itd inhibitor clifutinib
9e </ b
50 </ sub
positive aml
promising target
potently suppressed
poor prognosis
like properties
itd kinase
itd inhibitors
clinical trials
biphenylacetylene derivatives
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