Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx
Background<p>Lymphedema, a chronic condition involving lymphatic fluid accumulation, affects over 250 million people worldwide. Liposuction (LS), introduced in 1989, offers a minimally invasive option for non-pitting lymphedema by reducing fibrotic and hypertrophic tissues. However, LS require...
Enregistré dans:
| Auteur principal: | |
|---|---|
| Autres auteurs: | , , , , |
| Publié: |
2025
|
| Sujets: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1849927624223096832 |
|---|---|
| author | Junzhe Chen (5729912) |
| author2 | Xiyao Feng (8949869) Yan Zhou (6523) Yun Wang (32846) Shune Xiao (4109980) Chengliang Deng (10529766) |
| author2_role | author author author author author |
| author_facet | Junzhe Chen (5729912) Xiyao Feng (8949869) Yan Zhou (6523) Yun Wang (32846) Shune Xiao (4109980) Chengliang Deng (10529766) |
| author_role | author |
| dc.creator.none.fl_str_mv | Junzhe Chen (5729912) Xiyao Feng (8949869) Yan Zhou (6523) Yun Wang (32846) Shune Xiao (4109980) Chengliang Deng (10529766) |
| dc.date.none.fl_str_mv | 2025-11-26T05:15:27Z |
| dc.identifier.none.fl_str_mv | 10.3389/fonc.2025.1651472.s002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_3_Outcomes_after_liposuction-based_treatment_of_lymphedema_a_systematic_review_and_meta-analysis_docx/30717836 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Oncology and Carcinogenesis not elsewhere classified lymphedema surgery integrated surgery liposuction meta-analysis |
| dc.title.none.fl_str_mv | Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Background<p>Lymphedema, a chronic condition involving lymphatic fluid accumulation, affects over 250 million people worldwide. Liposuction (LS), introduced in 1989, offers a minimally invasive option for non-pitting lymphedema by reducing fibrotic and hypertrophic tissues. However, LS requires ongoing compression therapy as it does not address the underlying lymphatic dysfunction. Although integrated approaches combining LS with lymphovenous anastomosis (LVA) or vascularized lymph node transfer (VLNT) aim to address both fluid removal and lymphatic repair, there remains a lack of consensus regarding the efficacy of these integrated liposuction-based treatments.</p>Methods<p>A systematic review and meta-analysis conducted by the PRISMA and AMSTAR guidelines included studies from 1996 to 2024. Fifty-two studies (n=2,334) were reviewed and 23 (n=1,028) were analyzed quantitatively. Outcomes mainly included limb volume reduction, reliance on conservative treatment, improvement in infection rates, and improvement in the quality of life (QOL).</p>Results<p>LS-based treatments significantly reduce volume in both upper and lower limbs (91.08% and 92.03%). Standalone LS reduced limb volume by 99.74% but relied on continuous compression therapy. Combined approaches achieved slightly lower reductions (87.31%), but significantly decreased compression dependence, improved lymphatic function, and enhanced QOL. Furthermore, LS-based interventions were associated with a potential reduction in infection episodes, thereby providing long-term benefits.</p>Conclusion<p>Liposuction-based therapies effectively manage lymphedema by reducing limb volume and may reduce infections, while improving QOL. In addition, integrated approaches offer additional benefits by directly addressing lymphatic dysfunction and reducing reliance on compression therapy. Standardized methodologies and long-term studies are needed to refine the clinical guidelines and optimize outcomes. </p>Systematic review registration<p>https://www.crd.york.ac.uk/PROSPERO, identifier CRD42024616130.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_41a663c000603a03bba001a432a338ae |
| identifier_str_mv | 10.3389/fonc.2025.1651472.s002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30717836 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docxJunzhe Chen (5729912)Xiyao Feng (8949869)Yan Zhou (6523)Yun Wang (32846)Shune Xiao (4109980)Chengliang Deng (10529766)Oncology and Carcinogenesis not elsewhere classifiedlymphedemasurgeryintegrated surgeryliposuctionmeta-analysisBackground<p>Lymphedema, a chronic condition involving lymphatic fluid accumulation, affects over 250 million people worldwide. Liposuction (LS), introduced in 1989, offers a minimally invasive option for non-pitting lymphedema by reducing fibrotic and hypertrophic tissues. However, LS requires ongoing compression therapy as it does not address the underlying lymphatic dysfunction. Although integrated approaches combining LS with lymphovenous anastomosis (LVA) or vascularized lymph node transfer (VLNT) aim to address both fluid removal and lymphatic repair, there remains a lack of consensus regarding the efficacy of these integrated liposuction-based treatments.</p>Methods<p>A systematic review and meta-analysis conducted by the PRISMA and AMSTAR guidelines included studies from 1996 to 2024. Fifty-two studies (n=2,334) were reviewed and 23 (n=1,028) were analyzed quantitatively. Outcomes mainly included limb volume reduction, reliance on conservative treatment, improvement in infection rates, and improvement in the quality of life (QOL).</p>Results<p>LS-based treatments significantly reduce volume in both upper and lower limbs (91.08% and 92.03%). Standalone LS reduced limb volume by 99.74% but relied on continuous compression therapy. Combined approaches achieved slightly lower reductions (87.31%), but significantly decreased compression dependence, improved lymphatic function, and enhanced QOL. Furthermore, LS-based interventions were associated with a potential reduction in infection episodes, thereby providing long-term benefits.</p>Conclusion<p>Liposuction-based therapies effectively manage lymphedema by reducing limb volume and may reduce infections, while improving QOL. In addition, integrated approaches offer additional benefits by directly addressing lymphatic dysfunction and reducing reliance on compression therapy. Standardized methodologies and long-term studies are needed to refine the clinical guidelines and optimize outcomes. </p>Systematic review registration<p>https://www.crd.york.ac.uk/PROSPERO, identifier CRD42024616130.</p>2025-11-26T05:15:27ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fonc.2025.1651472.s002https://figshare.com/articles/dataset/Table_3_Outcomes_after_liposuction-based_treatment_of_lymphedema_a_systematic_review_and_meta-analysis_docx/30717836CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307178362025-11-26T05:15:27Z |
| spellingShingle | Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx Junzhe Chen (5729912) Oncology and Carcinogenesis not elsewhere classified lymphedema surgery integrated surgery liposuction meta-analysis |
| status_str | publishedVersion |
| title | Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx |
| title_full | Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx |
| title_fullStr | Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx |
| title_full_unstemmed | Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx |
| title_short | Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx |
| title_sort | Table 3_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx |
| topic | Oncology and Carcinogenesis not elsewhere classified lymphedema surgery integrated surgery liposuction meta-analysis |