Integration of experimental data from MR in dogs and VO in rats.

<p>Each plot shows fold changes in one reported measure, plotted as a function of time normalized by the time constant of an exponential equation fitted to the LVM/BW data. a) LVM/BM data from sixteen articles (41 datasets) on experimental MR in dogs [<a href="http://www.ploscompbiol.o...

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Bibliographic Details
Main Author:	Johane H. Bracamonte (12883844) (author)
Other Authors:	Lionel Watkins (21101254) (author), Betty Pat (15336130) (author), Louis J. Dell’Italia (8770514) (author), Jeffrey J. Saucerman (8131425) (author), Jeffrey W. Holmes (6087089) (author)
Published:	2025
Subjects:	Medicine Biological Sciences not elsewhere classified Information Systems not elsewhere classified treat heart failure provide significant recovery myocardial tissue stretch mitral valve repair increased myocyte strain calibrated model predicts based network model intracellular signaling network compensatory neurohormonal responses alters mechanical loading ventricular volume overload experimental volume overload cardiac hypertrophy driven mechanical loading overload hypertrophy volume overload neurohormonal response hypertrophic signaling expected responses cardiac function mostly driven eccentric hypertrophy driven primarily treated according time course questions remain quantitative predictions promising approach potential interventions optimal timing operatively despite observation contrasts multiple studies left ventricle known structure knowledge gap integrate information initial increase including infusion hypertrophic process experimental vo current guidelines common perception combine data better understanding better personalize bayesian approach 70 studies 43 studies
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Integration of experimental data from MR in dogs and VO in rats.

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