Fusion detection in cancer (n = 613).

<div><p>Kinase-related gene fusion and point mutations play pivotal roles as drivers in cancer, necessitating optimized, targeted therapy against these alterations. The efficacy of molecularly targeted therapeutics varies depending on the specific alteration, with great success reported...

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Main Author:	Shinsuke Suzuki (431254) (author)
Other Authors:	Toshiaki Akahane (6843287) (author), Akihide Tanimoto (663645) (author), Michiyo Higashi (120435) (author), Ikumi Kitazono (9112776) (author), Mari Kirishima (11543458) (author), Masakazu Nishigaki (20606146) (author), Toshiro Ikeda (20606149) (author), Shuichi Kanemitsu (18481363) (author), Junichi Nakazawa (11898846) (author), Erina Akahane (20606152) (author), Hiroshi Nishihara (148950) (author), Kimiharu Uozumi (13965539) (author), Makoto Yoshimitsu (520434) (author), Kenji Ishitsuka (3706342) (author), Shin-ichi Ueno (13965548) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Developmental Biology Cancer Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified great success reported related gene fusion fusions involving kinases identified 117 patients liquid companion diagnostic div >< p kinase fusion proteins detecting kinase alterations copy number alterations analyzed 613 patients companion diagnostic 613 patients kinase fusion kinase fusions fusion calling domain fusion domain fusions actionable alterations tumor suppressors transcriptional regulators targeted therapy specific alteration solid tumors remains unclear prime targets pivotal role patient characteristics necessitating optimized june 2020 iqr ]) interquartile range genomic profiles findings underscore f1lcdx ). april 2024
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Fusion detection in cancer (n = 613).

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