Fusion detection in cancer (n = 613).

Fusion detection in cancer (n = 613).

<div><p>Kinase-related gene fusion and point mutations play pivotal roles as drivers in cancer, necessitating optimized, targeted therapy against these alterations. The efficacy of molecularly targeted therapeutics varies depending on the specific alteration, with great success reported...

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Bibliographic Details
Main Author: Shinsuke Suzuki (431254) (author)
Other Authors: Toshiaki Akahane (6843287) (author), Akihide Tanimoto (663645) (author), Michiyo Higashi (120435) (author), Ikumi Kitazono (9112776) (author), Mari Kirishima (11543458) (author), Masakazu Nishigaki (20606146) (author), Toshiro Ikeda (20606149) (author), Shuichi Kanemitsu (18481363) (author), Junichi Nakazawa (11898846) (author), Erina Akahane (20606152) (author), Hiroshi Nishihara (148950) (author), Kimiharu Uozumi (13965539) (author), Makoto Yoshimitsu (520434) (author), Kenji Ishitsuka (3706342) (author), Shin-ichi Ueno (13965548) (author)
Published: 2025
Subjects:
Biochemistry
Medicine
Cell Biology
Genetics
Molecular Biology
Developmental Biology
Cancer
Science Policy
Infectious Diseases
Virology
Biological Sciences not elsewhere classified
great success reported
related gene fusion
fusions involving kinases
identified 117 patients
liquid companion diagnostic
div >< p
kinase fusion proteins
detecting kinase alterations
copy number alterations
analyzed 613 patients
companion diagnostic
613 patients
kinase fusion
kinase fusions
fusion calling
domain fusion
domain fusions
actionable alterations
tumor suppressors
transcriptional regulators
targeted therapy
specific alteration
solid tumors
remains unclear
prime targets
pivotal role
patient characteristics
necessitating optimized
june 2020
iqr ])
interquartile range
genomic profiles
findings underscore
f1lcdx ).
april 2024
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