Enantiospecific Synthesis of Planar Chiral Rhodium and Iridium Cyclopentadienyl Complexes: Enabling Streamlined and Computer-Guided Access to Highly Selective Catalysts for Asymmetric C–H Functionalizations

Chiral cyclopentadienyl (Cp<sup>X</sup>) metal complexes are frequently used in asymmetric catalysis by virtue of their high reactivity and selectivity. Planar-chiral-only rhodium and iridium cyclopentadienyl complexes are particularly promising due to unrestricted chemical space for Cp&...

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Bibliographic Details
Main Author:	Young Sebastian Ye (20396906) (author)
Other Authors:	Aragorn Laverny (9674916) (author), Matthew D. Wodrich (1263717) (author), Ruben Laplaza (5641283) (author), Farzaneh Fadaei-Tirani (7066340) (author), Rosario Scopelliti (1328478) (author), Clemence Corminboeuf (1938136) (author), Nicolai Cramer (1516678) (author)
Published:	2024
Subjects:	Biochemistry Molecular Biology Evolutionary Biology Immunology Cancer Plant Biology Space Science Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified various challenging alkenes unrestricted chemical space typical stereoablative complexation retaining structural simplicity refractory alkene substrates particularly promising due olefin )< sub oac ]< sub excellent catalytic performance currently still niche achiral cyclopentadienyl anion 2 </ sub highly selective catalysts efficient synthetic strategies planar chirality transfer enantiospecific complexation step suitable chiral cyclopentadienes x </ sup structurally diverse library iridium cyclopentadienyl complexes computational selectivity predictions planar chiral rhodium highly enantiospecific efficient one enantiospecific synthesis chiral cyclopentadiene streamline access preceding au pot process poor selectivity optimize reactivity likely involves ligand design high selectivity high reactivity frequently used entirely avoids enabling streamlined detrimentally yields catalyzed cyclization carboxylate precursor asymmetric catalysis
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Enantiospecific Synthesis of Planar Chiral Rhodium and Iridium Cyclopentadienyl Complexes: Enabling Streamlined and Computer-Guided Access to Highly Selective Catalysts for Asymmetric C–H Functionalizations

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