Enantiospecific Synthesis of Planar Chiral Rhodium and Iridium Cyclopentadienyl Complexes: Enabling Streamlined and Computer-Guided Access to Highly Selective Catalysts for Asymmetric C–H Functionalizations

Enantiospecific Synthesis of Planar Chiral Rhodium and Iridium Cyclopentadienyl Complexes: Enabling Streamlined and Computer-Guided Access to Highly Selective Catalysts for Asymmetric C–H Functionalizations

Chiral cyclopentadienyl (Cp<sup>X</sup>) metal complexes are frequently used in asymmetric catalysis by virtue of their high reactivity and selectivity. Planar-chiral-only rhodium and iridium cyclopentadienyl complexes are particularly promising due to unrestricted chemical space for Cp&...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Young Sebastian Ye (20396906) (author)
مؤلفون آخرون: Aragorn Laverny (9674916) (author), Matthew D. Wodrich (1263717) (author), Ruben Laplaza (5641283) (author), Farzaneh Fadaei-Tirani (7066340) (author), Rosario Scopelliti (1328478) (author), Clemence Corminboeuf (1938136) (author), Nicolai Cramer (1516678) (author)
منشور في: 2024
الموضوعات:
Biochemistry
Molecular Biology
Evolutionary Biology
Immunology
Cancer
Plant Biology
Space Science
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
various challenging alkenes
unrestricted chemical space
typical stereoablative complexation
retaining structural simplicity
refractory alkene substrates
particularly promising due
olefin )< sub
oac ]< sub
excellent catalytic performance
currently still niche
achiral cyclopentadienyl anion
2 </ sub
highly selective catalysts
efficient synthetic strategies
planar chirality transfer
enantiospecific complexation step
suitable chiral cyclopentadienes
x </ sup
structurally diverse library
iridium cyclopentadienyl complexes
computational selectivity predictions
planar chiral rhodium
highly enantiospecific
efficient one
enantiospecific synthesis
chiral cyclopentadiene
streamline access
preceding au
pot process
poor selectivity
optimize reactivity
likely involves
ligand design
high selectivity
high reactivity
frequently used
entirely avoids
enabling streamlined
detrimentally yields
catalyzed cyclization
carboxylate precursor
asymmetric catalysis
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