Image 3_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff

Image 3_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff

Aims<p>Cathepsins are essential lysosomal enzymes that maintain organismal homeostasis by degrading extracellular substrates. The inflammatory cytokine interleukin-6 (IL-6) increases the production of cathepsins through the caveolin-1 (Cav-1) and c-Jun N-terminal kinase (JNK) signaling pathway...

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Bibliographic Details
Main Author: Ayaka Goto (20858771) (author)
Other Authors: Kazuhiro Omori (2394982) (author), Tomoko Yamaguchi-Tomikawa (8936996) (author), Hiroya Kobayashi (3931256) (author), Yuki Shinoda-Ito (20858774) (author), Kimito Hirai (8936993) (author), Atsushi Ikeda (1733572) (author), Shogo Takashiba (63612) (author)
Published: 2025
Subjects:
Dentistry not elsewhere classified
cathepsin B
cathepsin L
human gingival fibroblast
interleukin-6
caveolin
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