Bioengineering Approaches for the 3D Blood–Retinal Barrier: Disease Modeling and Drug Development

Bioengineering Approaches for the 3D Blood–Retinal Barrier: Disease Modeling and Drug Development

The integrity and functionality of the blood–retina barrier (BRB) are essential for maintaining homeostasis of the retina. Disruption of the BRB is a key feature in different stages of retinal diseases including diabetic retinopathy, age-related macular degeneration (AMD), and inherited retinal dise...

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Bibliographic Details
Main Author: Ruiyi Yan (4594162) (author)
Other Authors: Yusong Wang (1467721) (author), Yinhan Wang (18289599) (author), Mingchang Pang (22283574) (author), Linfei Wei (22283577) (author), Meijiao Zhu (9758954) (author), Huayu Yang (6328412) (author), Weihong Yu (11091709) (author)
Published: 2025
Subjects:
Medicine
Genetics
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
traditional 2d cultures
past three years
extracellular matrix scaffolds
commonly used techniques
related macular degeneration
xenogeneic animal models
brb holds promise
inherited retinal diseases
retinal diseases
related diseases
vitro models
brb models
vivo brb
translational medicine
therapeutic strategies
simple constructs
significant interest
retinitis pigmentosa
recent advances
powerful armament
new developments
maintaining homeostasis
laboratory research
key feature
investigating mechanistic
functional characteristics
emphasizing applications
drug screening
drug development
disease modeling
disease evolution
different stages
complex systems
biomaterials employed
bioengineering approaches
amd ),
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