Oxytocin decreases locally evoked CeA GABAergic signaling and blunts alcohol effects.

Oxytocin decreases locally evoked CeA GABAergic signaling and blunts alcohol effects.

<p>(A) Representative eIPSPs recorded from CeA neurons of nondependent (upper) and dependent (lower) rats before (baseline) and during acute application of oxytocin (500 nM), oxytocin with alcohol (44 mM), and alcohol alone. (B) Effect of 3 concentrations of oxytocin (100, 500, and 1,000 nM) o...

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Bibliographic Details
Main Author: Brendan J. Tunstall (6593357) (author)
Other Authors: Dean Kirson (6593360) (author), Lia J. Zallar (6593363) (author), Sam A. McConnell (6593366) (author), Janaina C. M. Vendruscolo (6593369) (author), Chelsea P. Ho (6593372) (author), Christopher S. Oleata (6593375) (author), Sophia Khom (1326369) (author), Maurice Manning (2890697) (author), Mary R. Lee (344980) (author), Lorenzo Leggio (504771) (author), George F. Koob (451320) (author), Marisa Roberto (5625170) (author), Leandro F. Vendruscolo (367134) (author)
Published: 2019
Subjects:
Biochemistry
Medicine
Neuroscience
Physiology
Pharmacology
Biotechnology
Mental Health
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
alcohol use disorder
alcohol dependence
amygdala Oxytocin administration
GABAergic transmission
Ex vivo electrophysiological recordings
PF
nondependent rats
alcohol drinking
Intranasal oxytocin delivery
dependence-induced alcohol drinking
Intraperitoneal oxytocin administration
CeA GABA transmission
blocks alcohol effects
oxytocin receptor antagonist
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