Artificial engineering of a full-length gorilla CYP4B1.

<p><b>(A)</b> cDNA sequence of wild type gorilla CYP4B1 and engineered gorilla CYP4B1 containing human exon 10 and gorilla exon 10 (corresponding to human exon 11) and full-length gorilla exon 11 (corresponding to human exon 12). The amino acid sequence of the 3’ human exon 10 that...

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Autore principale:	Saskia Hüsken (21616072) (author)
Altri autori:	Annika Röder (21616075) (author), Johannes Ptok (9283781) (author), Anne E. Meyer (21616078) (author), Mats Georg (21380052) (author), Yannick Schwarz (21616081) (author), Christian Roos (141269) (author), Kerstin Mätz-Rensing (365237) (author), Michael C. Hutter (2372869) (author), Doreen M. Floss (21616084) (author), Allan E. Rettie (219933) (author), Marco Girhard (3400892) (author), Helmut Hanenberg (140467) (author), Constanze Wiek (140463) (author)
Pubblicazione:	2025
Soggetti:	Biochemistry Microbiology Genetics Molecular Biology Neuroscience Evolutionary Biology Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified exon deletion found closely related species 14 primate genera human liver cells hydroxylate lauric acid amino acid analysis div >< p native human cyp4b1 tested cyp4b1 orthologs lauric acid cyp4b1 orthologs human evolution human enzymes functional analysis also tested inactivating cyp4b1 gorilla cyp4b1 cyp4b1 inactivation cyp4b1 enzymes v71g specific ultimately improve perilla ketone negative impact genetic changes evolutionary trigger endobiotic substrates coli </ clear indication
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Artificial engineering of a full-length gorilla CYP4B1.

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