Image 1_GPR83 protects cochlear hair cells against ibrutinib-induced hearing loss through AKT signaling pathways.pdf

Image 1_GPR83 protects cochlear hair cells against ibrutinib-induced hearing loss through AKT signaling pathways.pdf

Introduction<p>Ibrutinib, widely used in leukemia treatment, has been implicated in sensorineural hearing loss; however, its underlying mechanisms remain unclear.</p>Methods<p>This study investigated the impact of ibrutinib on hearing using HEI-OC1 cells, cochlear explants and C57B...

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Main Author: Yuhua Zhang (57349) (author)
Other Authors: Yun Xiao (14988) (author), Yongjun Zhu (2794957) (author), Lin Yan (53104) (author), Nan Cheng (138414) (author), Yongjie Wei (2430100) (author), Yanling Zhang (6561) (author), Yanghua Tian (343301) (author), Wei Cao (50866) (author), Jianming Yang (186197) (author)
Published: 2025
Subjects:
Foetal Development and Medicine
ibrutinib
hearing loss
hair cell
G protein-coupled receptor
Z-VAD-FMK
apoptosis
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