Overexpression of GPI biosynthesis genes does not alter coronavirus infection.

HeLa cells transduced with lentiviruses expressing PIGA or PIGV or a control vector were infected with HCoV-229E (MOI 0.75, 32 h), PEDV (MOI 1, 20 h), HCoV-OC43 (MOI 0.5, 20 h), IBV (MOI 0.75, 20 h), or PDCoV (MOI 0.25, 17 h). Virus infection efficiency...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Yanlong Ma (3922220) (author)
مؤلفون آخرون:	Fei Feng (427513) (author), Hui Feng (174331) (author), Xue Ma (67782) (author), Ziqiao Wang (6730244) (author), Yutong Han (5447690) (author), Yunkai Zhu (4349152) (author), Yuyan Wang (283747) (author), Zhichao Gao (4261183) (author), Yuyuan Zhang (1275144) (author), Qiang Ding (295913) (author), Jincun Zhao (200043) (author), Rong Zhang (44942) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Physiology Biotechnology Evolutionary Biology Ecology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified various cellular processes playing essential roles disrupting spike protein coronavirus restriction factor counteract viral infections coronavirus host factor mediated membrane fusion covalently anchor proteins restrict viral entry host restriction factors coronaviruses via regulation glycosylphosphatidylinositol biosynthesis functions div >< p gpi biosynthesis pathway ly6e </ p viral entry host factors cell membrane anchored proteins betacoronavirus </ alphacoronavirus </ gpi biosynthesis identified ly6e identified glycosylphosphatidylinositol plasma membranes including sars findings reveal conducted genome antiviral activity
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Overexpression of GPI biosynthesis genes does not alter coronavirus infection.

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