Looking into the Quest for Stereoselective Ring-Opening Polymerization of Racemic Lactide with Chiral Organocatalysts

Looking into the Quest for Stereoselective Ring-Opening Polymerization of Racemic Lactide with Chiral Organocatalysts

A model for stereoselective ring-opening polymerization (ROP) of racemic lactide (<i>rac</i>-LA) catalyzed by chiral thiourea-based organocatalysts is presented based on density functional theory (DFT) calculations. The model reveals the complex mechanism of the process, highlighting (a)...

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Bibliographic Details
Main Author: Rachele Zunino (19333398) (author)
Other Authors: Laura Falivene (1414534) (author), Giovanni Talarico (40253) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Genetics
Molecular Biology
Neuroscience
Biotechnology
Evolutionary Biology
Immunology
Chemical Sciences not elsewhere classified
multiple mechanistic pathways
density functional theory
demonstrating good agreement
enantiomorphic site control
based bifunctional catalysts
racemic lactide (<
>- la ),
racemic lactide
>- la
end control
presented based
based organocatalysts
stereoselective ring
providing insights
opening polymerization
nucleophilic addition
monomer chirality
experimental stereoselectivity
enantioselective activation
determining steps
complex mechanism
chiral thiourea
chiral organocatalysts
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