Pan-cancer analyses of GSRS.

Pan-cancer analyses of GSRS.

<p>(<b>A</b>) Tumor samples showed significantly higher levels of GSRS in 16 out of 33 cancer types compared to adjacent paracarcinoma tissues, indicating a potential role of glucocorticoid signaling in tumorigenesis. (<b>B</b>) The predictive ability of GSRS for OS acr...

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Bibliographic Details
Main Author: Yu Zhang (12946) (author)
Other Authors: Chen Chen (6544) (author), Tianhang Zhu (22421568) (author), Wei Luo (80175) (author), Ranran Zhou (6503195) (author), Wanlong Tan (311259) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Genetics
Molecular Biology
Physiology
Immunology
Developmental Biology
Marine Biology
Cancer
Hematology
Biological Sciences not elsewhere classified
world clinical settings
vivo experiments showed
spatial transcriptomics revealed
pooled hazard ratio
offering valuable insights
healthy donors (<
05 – 3
gene signature emerged
random forest analyses
cell exhaustion levels
related gene signature
div >< p
related genes
decreased levels
cell infiltration
05 ).
subsequently incorporated
rigorously validated
prognostic significance
predictive tool
positive association
pivotal role
p </
msigdb database
local samples
immunotherapeutic response
glucocorticoids play
glucocorticoid signaling
experimentally validating
corticosterone treatment
confidence interval
computational simulations
cancer progression
65 ).
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