Pan-cancer analyses of GSRS.
<p>(<b>A</b>) Tumor samples showed significantly higher levels of GSRS in 16 out of 33 cancer types compared to adjacent paracarcinoma tissues, indicating a potential role of glucocorticoid signaling in tumorigenesis. (<b>B</b>) The predictive ability of GSRS for OS acr...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , |
| Published: |
2025
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <p>(<b>A</b>) Tumor samples showed significantly higher levels of GSRS in 16 out of 33 cancer types compared to adjacent paracarcinoma tissues, indicating a potential role of glucocorticoid signaling in tumorigenesis. (<b>B</b>) The predictive ability of GSRS for OS across a pan-cancer level, demonstrating its potential as a prognostic biomarker. (<b>C-D</b>) Higher GSRS levels were associated with unfavorable OS in kidney renal papillary cell carcinoma (KIRP) (<b>C</b>) and acute myeloid leukemia (LAML) (<b>D</b>), suggesting a negative prognostic impact in these cancers. (<b>E-F</b>) Conversely, higher GSRS levels were linked to favorable OS in lower grade glioma (LGG) (<b>E</b>) and sarcoma (SARC) (<b>F</b>), indicating a potential protective or beneficial role in these cancer types.</p> <p>(TIF)</p> |
|---|