De Novo Design of Mirror-Image Dimeric Antimicrobial Peptides with Low Drug Resistance and In Vivo Efficacy

Dimerization and mirror-image modification are effective strategies for enhancing the antimicrobial activity and stability of antimicrobial peptides (AMPs). However, mirror-image dimeric AMPs, characterized by their mirror-image amino acid sequences and mirror-image stereocenters within a single pep...

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Հիմնական հեղինակ:	Jingying Zhang (1637071) (author)
Այլ հեղինակներ:	Anqi Chu (20395427) (author), Ping Yang (56755) (author), Xu Ouyang (9326058) (author), Beibei Li (280092) (author), Wenbo Mao (9697286) (author), Xiaoyan Wu (235931) (author), Chao Zhong (2247550) (author), Sanhu Gou (10003604) (author), Yun Zhang (131894) (author), Hui Liu (33624) (author), Jingman Ni (1856836) (author)
Հրապարակվել է:	2025
Խորագրեր:	Biochemistry Microbiology Pharmacology Biotechnology Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified robust membrane disruption high dna affinity de novo design image stereocenters within kg ), along image dimeric amps vivo efficacy dimerization low drug resistance drug resistance vivo efficacy image modification low propensity vivo half type amps amps ). type residues superior peptide standout candidate single peptide satisfactory safety resistant bacteria represents cationic rarely reported promising avenue immunoregulatory activity hydrophobic residues antimicrobial activity 7 min 5 mg 4 min 10 mg
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De Novo Design of Mirror-Image Dimeric Antimicrobial Peptides with Low Drug Resistance and In Vivo Efficacy

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