Gene expression response to USF depletion and IR.

<p>(A and B) Venn diagrams of DEG transcripts that exhibited >1.50-fold increase (A) or >1.50-fold decrease (B) in expression in either USFKD no IR or USFKD 7d IR cells relative to sshRNA no IR. Numbers of DEG transcripts present only in untreated samples (green circles), 7d IR samples (...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Kimberly S. Bellingham-Johnstun (21714063) (author)
مؤلفون آخرون:	Lisa A. Metzger (21714066) (author), Jennifer L. Stone (21714069) (author), Kevin Gerrish (69694) (author), Pierre R. Bushel (9015944) (author), Michael L. Sikes (13389993) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Immunology Developmental Biology Cancer Hematology Plant Biology Biological Sciences not elsewhere classified therapeutic resistance remains stranded dna breaks scrambled control shrna roughly half shared simultaneously depleting cells healthy cells exposed cells exhibited widespread cell types ). >) gene expression dna damage pathways div >< p distinct transcriptional responses gene expression response cancer cells exploit transcriptional responses transformed cells lymphoma cells independent response cells expressing cell cycle 5b3 cells curing cancer cancer therapies tcrb </ stresses induced single sublethal seven days primary obstacle previously found potential role microarray findings lymphocytes utilize j recombination irradiated controls ionizing radiation independent role independent non immune development genotoxic therapy genetic programs genes responsive genes linked genes critical fold change findings shed 5 gy
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Gene expression response to USF depletion and IR.

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