SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] (A) Heatmap of absolute mean SHAP values for different algorithms DeepSHAP, KernelSHAP and TreeSHAP is plotted for direct targets (blue) and random genes (black) following INTS11 degradation, SET1A degradation, ZC3H4 degradation and SET1A+ZC3H4 degradation simultaneously.

SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] (A) Heatmap of absolute mean SHAP values for different algorithms DeepSHAP, KernelSHAP and TreeSHAP is plotted for direct targets (blue) and random genes (black) following INTS11 degradation, SET1A degradation, ZC3H4 degradation and SET1A+ZC3H4 degradation simultaneously.

<p>(B) Overlap of direct targets of SET1A, ZC3H4 and INTS11. (C) Scatter plot of <i>log</i><sub>2</sub> fold changes following ZC3H4 degradation and INTS11 degradation for the overlapping genes. (D) Scatter plot of <i>log</i><sub>2</sub> fold cha...

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Bibliographic Details
Main Author:	Kashyap Chhatbar (9515350) (author)
Other Authors:	Adrian Bird (84938) (author), Guido Sanguinetti (343362) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Marine Biology Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified suggesting crosstalk mediated shapley additive explanations predict rna pol mechanistically remains challenging infer functional relevance dependent regulatory networks integrating predictive modelling insights using data based perturbation experiments associated protein profiles unravel complex context unperturbed data perturbation even modelling transcription associated proteins restrictor complex integrator complex compass complex unperturbed conditions transcriptional regulation transcriptional changes influencing transcription ii occupancy genes ranked gene bodies findings highlight experimental validation cooperative roles analysis reveals also captures
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