Statistical Definitions and Relationships. On the left different comparisons are shown. Intra- and interreader comparisons (same and different readers) are used to calculate tolerance ranges (BTR and VTR). The BTR/VTR contains 95% of evaluation differences for an intrareader/interreader comparison. The AI’s performance is acceptable if its confidence interval (CI) is covered by the BTR, and its tolerance interval (TI) is covered by the VTR. The CI covers the bias with a confidence of 95%, the TI covers a configurable portion (i.e., ) of the differences with a confidence of 95%. These relationships are depicted in the Reliability Plot, in which the CI (red diamond) leaves the BTR (grey area), but the TI (blue lines) is covered by the VTR (dark grey lines). Legend: BTR: bias tolerance range, VTR: variance tolerance range, CI: 95%-confidence interval, TI: tolerance interval, std: standard deviation, : critical value of normal distribution of the cumulative probability (1 + p)/2, : cri

<p>Statistical Definitions and Relationships. On the left different comparisons are shown. Intra- and interreader comparisons (same and different readers) are used to calculate tolerance ranges (BTR and VTR). The BTR/VTR contains 95% of evaluation differences for an intrareader/interreader com...

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