Prior infection with B.1 (614G) protects the lungs of hamsters from subsequent challenge with B.1.427 or B.1.429.

A) sgRNA levels and infectious virus titer in lungs of hamsters infected with B.1 (614G) and necropsied at 2 days (N = 5) and 21 days PI (N = 5), and 5 hamsters that were challenged at day 21 PI with homologous B.1 (614G) and necropsied at day 23 PI. B)...

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Main Author:	Timothy Carroll (3762841) (author)
Other Authors:	Douglas Fox (9382991) (author), Neeltje van Doremalen (202274) (author), Erin Ball (12072826) (author), Mary Kate Morris (12072829) (author), Alicia Sotomayor-Gonzalez (12072832) (author), Venice Servellita (12072835) (author), Arjun Rustagi (12072838) (author), Claude Kwe Yinda (10005240) (author), Linda Fritts (106123) (author), Julia Rebecca Port (12072841) (author), Zhong-Min Ma (267325) (author), Myndi G. Holbrook (10005255) (author), Jonathan Schulz (12072844) (author), Catherine A. Blish (3779170) (author), Carl Hanson (11642558) (author), Charles Y. Chiu (6639926) (author), Vincent Munster (530915) (author), Sarah Stanley (423063) (author), Christopher J. Miller (106133) (author)
Published:	2022
Subjects:	Microbiology Cell Biology Biotechnology Evolutionary Biology Ecology Immunology Cancer Mental Health Infectious Diseases Virology Environmental Sciences not elsewhere classified vivo competition experiments syrian hamster model subgenomic viral rna severe lung pathology observe significant differences moderate size niche dramatically outcompete alpha decreased antibody neutralization cause severe disease 7 ), beta syrian hamsters compared early january 2021 429 infections relative 2 variants continue however sgrna levels 614g ), gamma 614g ), epsilon 614g ), three variants 3 variants 2 variants xlink "> vaccine recipients rapidly assessed originally detected oral swabs nasal cavity late stages induced immunity higher levels hamsters infected faster dissemination existing immunity evade vaccine epsilon dominate enhanced infectivity convalescent patients animal models also observed 429 replicates 429 causing 427 infections
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Prior infection with B.1 (614G) protects the lungs of hamsters from subsequent challenge with B.1.427 or B.1.429.

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