Low UDP-GlcA levels in female mouse kidneys.

<p><b>(A)</b> Schematic overview of the ELISA-based assay developed to quantify UDP-GlcA levels. This method utilizes immobilized asialorosomucoid (ASOR) as a GlcA-accepting substrate and purified recombinant GlcAT-P to enzymatically transfer GlcA from UDP-GlcA to N-acetyllactosami...

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Bibliographic Details
Main Author:	Tomoko Onishi (22615257) (author)
Other Authors:	Hajime Okayama (22615260) (author), Hitomi Kitano (22615263) (author), Katsuaki Higashi (18494352) (author), Naoki Nakagawa (648870) (author), Motohiro Nonaka (9946567) (author), Shogo Oka (782881) (author), Jyoji Morise (782879) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Immunology Marine Biology Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified thick ascending limb novel regulatory mechanism findings prompted us suggesting enhanced udp findings identify udp div >< p measure intracellular udp glucuronic acid modification 1 glycan exhibits 1 glycan biosynthesis glycans </ p female mice compared specific renal nshnk glca levels compared 1 glycan expression glucuronic acid female mice vivo </ intracellular availability renal nshnk renal expression glca levels expression levels p also male mice knockout mice taken together strictly regulated specifically expressed significantly higher quantitative elisa proximal tubules primarily focused previous studies possible contributor methylumbelliferone suppressed male kidneys key determinant induced increase increased nshnk henle ’ glca consumption glca availability glca ), dependent increase acetyllactosamine structures >, wild 2 cells
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Low UDP-GlcA levels in female mouse kidneys.

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