EGL-19 CaV1 is upregulated in <i>unc-31</i> mutants, leading to enhanced postsynaptic excitability.

EGL-19 CaV1 is upregulated in <i>unc-31</i> mutants, leading to enhanced postsynaptic excitability.

<p><b>(A, B)</b> Endogenous expression of EGL-19 in muscle cells was quantified in wt (<i>n</i> = 12) and <i>unc-31</i> mutants (<i>n</i> = 16). Representative images (A; Scale bar 20 µm) and summary data (B) are shown. <b>(C, D)</b>...

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Bibliographic Details
Main Author:	Jiajie Shao (1729147) (author)
Other Authors:	Jana F. Liewald (21273553) (author), Wagner Steuer Costa (6813063) (author), Christiane Ruse (21273556) (author), Jens Gruber (4019942) (author), Mohammad S. Djamshedzad (21273559) (author), Wulf Gebhardt (21273562) (author), Alexander Gottschalk (129613) (author)
Published:	2025
Subjects:	Medicine Genetics Neuroscience Physiology Evolutionary Biology postsynaptic homeostatic scaling dense core vesicles synaptic functional properties increased muscle activation increased camp signaling mediate normal transmission caenorhabditis elegans </ chemical synaptic transmission identified neuropeptides involved gabaergic motor neurons div >< p 2 +</ sup reduced cholinergic transmission 31 muscle excitability 2 </ muscle cells neuropeptide signaling neurons fail motor circuit presynaptic transmission 31 </ synaptic plasticity type voltage regulates exocytosis presynaptic stimulation neuropeptides may neuropeptidergic regulation neuromuscular junction muscular l might compensate may also linking changes electrical activity double mutants compensatory changes act synergistically
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