Chemically Induced Nuclear Pore Complex Protein Degradation via TRIM21

Despite the exciting progress of bifunctional degrader molecules, also known as proteolysis-targeting chimeras (PROTACs), the rapidly expanding field is still significantly hampered by the lack of available E3 ligase ligands. Our research bridges this gap by uncovering a series of small-molecule lig...

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المؤلف الرئيسي:	Xiaomei Li (502923) (author)
مؤلفون آخرون:	Qingyang Wang (460264) (author), Anping Guo (2511964) (author), Yaping Qiu (6115442) (author), Qiuxia Chen (2477146) (author), You Li (238760) (author), Lanjun Zhang (449343) (author), Yaxin Guo (4475593) (author), Xiaoyun Meng (2353012) (author), Shiqian Li (349737) (author), Guizhi Liu (3208146) (author), Liyun Zhang (280172) (author), Jian Liu (33711) (author), Xianyang Li (5891825) (author), Longying Cai (14339445) (author), Xuemin Cheng (4042583) (author), Chuan Liu (367528) (author), Xiaotao Wang (1262121) (author), Andrew Wood (1403083) (author), James Murray (1397) (author), Guansai Liu (2117938) (author), Jin Li (119007) (author), Xiaodong Huang (1484986) (author), Dengfeng Dou (8713674) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Microbiology Cell Biology Genetics Molecular Biology Biotechnology Cancer Hematology Plant Biology Chemical Sciences not elsewhere classified using immunofluorescence techniques rapidly expanding field proteomic studies identified functional complex proteins trim21 using crystallography trim21 ligand treatment e3 ligase trim21 still significantly hampered bifunctional degrader molecules nup155 proteins impaired degradation required trim21 trim21 ligands significantly downregulated monovalent degrader targeting chimeras protacs ), primary target passenger target nuclear envelope novel mode molecule ligands initial degradation exciting progress encoded library cell death also known
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Chemically Induced Nuclear Pore Complex Protein Degradation via TRIM21

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