Linking Virulence and Iron Limitation Response in Staphylococcus aureus: The sRNA IsrR Is Involved in SaeRS Activation

Linking Virulence and Iron Limitation Response in Staphylococcus aureus: The sRNA IsrR Is Involved in SaeRS Activation

The Gram-positive opportunistic pathogen Staphylococcus aureus colonizes ∼30% of the human population but also causes various diseases. Precise regulation of genes involved in virulence and metabolic functions is required to adapt to changing host conditions, such as severe restriction of iron avail...

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Bibliographic Details
Main Author: Larissa M. Busch (21465383) (author)
Other Authors: Alexander Ganske (21465386) (author), Sebastian Reißel (21465389) (author), Lisa Bleul (17320110) (author), Christian Hentschker (5086931) (author), Hannes Wolfgramm (14184212) (author), Leif Steil (743556) (author), Manuela Gesell Salazar (7256699) (author), Marc Schaffer (226102) (author), Alexander Reder (706069) (author), Stephan Michalik (1997962) (author), Christiane Wolz (117043) (author), Kristin Surmann (4443844) (author), Uwe Völker (2058892) (author), Ulrike Mäder (11503036) (author)
Published: 2025
Subjects:
Medicine
Microbiology
Genetics
Molecular Biology
Neuroscience
Biotechnology
Immunology
Cancer
Hematology
Infectious Diseases
Virology
Biological Sciences not elsewhere classified
global regulator fur
based secretome analysis
changing host conditions
iron sparing response
iron limitation response
virulence factor production
sufficient conditions
nonessential iron
iron availability
taken together
severe restriction
saer regulon
sae system
protein levels
precise regulation
positively influenced
positively associated
nonexpressing strains
metabolic functions
mass spectrometry
linking virulence
isdabcdefgh </
human population
hemolysis activity
hemolysin levels
containing proteins
central metabolism
>- expressing
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