Schematic of the directed network flow entropy (DNFE) algorithm.

Schematic of the directed network flow entropy (DNFE) algorithm.

<p>(A) Given a set of control cells or samples and a corresponding set of case cells/samples at point T, we generated the specific directed network using rewire weighted gene co-expression network analysis with the direction determination index. (B) The global DNFE is calculated to pinpoint th...

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Bibliographic Details
Main Author: Xueqing Peng (10678527) (author)
Other Authors: Rui Qiao (458542) (author), Peiluan Li (6156950) (author), Luonan Chen (21547) (author)
Published: 2025
Subjects:
Biophysics
Cell Biology
Genetics
Molecular Biology
Developmental Biology
Cancer
Infectious Diseases
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
Information Systems not elsewhere classified
xlink "> typically
outperforms existing methods
identified &# 8220
dynamic biological processes
delay disastrous outcomes
six real datasets
one stable state
detecting tipping points
dynamic network biomarkers
method &# 8217
including three single
identifying critical states
critical state
tipping point
cell datasets
driving network
directed network
usually overlooked
scale data
sample data
numerical simulations
implemented based
dimensional small
cell rna
cell data
bulk data
blood dataset
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